منابع مشابه
Stabilization of Gp120 Outer Domain for Hiv-1-1 Vaccine Immunogen Design
The sole envelope glycoprotein spike on the surface of Human Immunodeficiency Virus (HIV-1) is composed of two subunits: gp120 and gp41. The gp120 consists of three domains: the inner domain, outer domain and bridging sheet, to which the viral primary receptor CD4 binds and induces a conformational change in gp120 to expose the co-receptor binding site. Previous studies have found that the oute...
متن کاملTryptophan 375 stabilizes the outer-domain core of gp120 for HIV vaccine immunogen design
The outer-domain core of gp120 may serve as a better HIV vaccine immunogen than the full-length gp120 because of its greater stability and immunogenicity. In our previous report, we introduced two disulfide bonds to the outer-domain core of gp120 to fix its conformation into a CD4-bound state, which resulted in a significant increase in its immunogenicity when compared to the wild-type outer-do...
متن کاملGeneration and Characterization of a Defective HIV-1 Virus as an Immunogen for a Therapeutic Vaccine
BACKGROUND The generation of new immunogens able to elicit strong specific immune responses remains a major challenge in the attempts to obtain a prophylactic or therapeutic vaccine against HIV/AIDS. We designed and constructed a defective recombinant virus based on the HIV-1 genome generating infective but non-replicative virions able to elicit broad and strong cellular immune responses in HIV...
متن کاملStrategies for an HIV vaccine
The development of an HIV vaccine poses an unprecedented challenge to the scientific community. The inexorable spread of HIV worldwide and the devastating clinical consequences of AIDS can only be contained by an effective vaccine. Yet, almost two decades after the first demonstration of HIV and its etiologic role in AIDS, this vaccine still is a goal, not a reality. In this Perspective, I cons...
متن کاملNew templates for HIV-1 antibody-based vaccine design
A current strategy for the design of neutralizing antibody-based vaccines to prevent HIV-1 transmission is that of reverse engineering, starting from a neutralizing antibody and working back to reconstruct its epitope by structure-based design technology. However, the field has been impeded by a lack of appropriate antibodies for use as templates. Recently, new antibodies have been described th...
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ژورنال
عنوان ژورنال: Virology Journal
سال: 2015
ISSN: 1743-422X
DOI: 10.1186/s12985-014-0221-0